October 2, 2025
Happy to report that this comparison study of using different imaging frequencies for super-resolution ULM led by Matt Lowerison has been published on The MIT Press Imaging Neuroscience (open access): https://direct.mit.edu/imag/article/doi/10.1162/IMAG.a.151/132868/Comparison-of-high-frequency-ultrasound
In this paper we established the advantage of using higher imaging frequencies to reduce the footprint of microbubble signals to facilitate more robust localization (and tracking) under high microbubble concentrations in the blood stream. With ULM, or CEUS, we are having the benefit of using highly echogenic microbubbles to overcome the higher acoustic attenuation of high frequency ultrasound waves. With the new Verasonics® NXT system, we can use up to 31.25 MHz imaging frequency without worrying about interleaved sampling, which is ideal for high-frequency ULM in rodent models.
