Our lab is active in the field of functional ultrasound (fUS) and functional ultrasound localization microscopy (fULM). fUS leverages the ultrafast imaging frame rate of ultrafast ultrasound to sense hemodynamic responses induced by neural activities, and fULM leverages contrast microbubbles to detect microvascular blood flow fluctuations that correlate with neural activities. Our lab is interested in developing novel computational imaging methods and instrumentations to enhance the performance of fUS and fULM and translate them to neuroscience basic research and neurological disease applications.
fUS:
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fULM:
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Related publications:
†Co-first author *Corresponding author
- Shin YR, Lowerison MR, Wang Y, Chen X, You Q, Dong Z, Anastasio MA, Song P*, “Context-Aware Deep Learning Enables High-Efficacy Localization of High Concentration Microbubbles for Super-resolution Ultrasound Localization Microscopy,” Nature Communications 15, no. 2932, 2024.
- Zhang J, Huang C, Lok UW, Liu H, Gong P, Song P, Chen S*, “Enhanced Row-column Array (RCA)-based 3D Ultrasound Vascular Imaging with Spatial-temporal Similarity Weighting,” IEEE Transactions on Medical Imaging (early access online).
- Applegate CC, Lowerison MR, Hambley E, Song P, Wallig MA, Erdman JW*, “Dietary Tomato Inhibits Angiogenesis in TRAMP Prostate Cancer But Is Not Protective With a Western-style Diet In This Pilot Study” Scientific Reports, 11:18548, pp. 1-13, 2021.
- Huang C, Song P, Gong P, Lok UW, Tang S, Trzasko JD, Manduca A, Chen S*, “Simultaneous Noise Suppression and Incoherent Artifact Reduction in Ultrafast Ultrasound Vascular Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 68, issue 6, pp. 2075-2085, 2021.
- Lok UW, Trzasko JD, Huang C, Tang S, Gong P, Lucien F, Kim Y, Lowerison MR, Song P, Chen S*, “Improved Ultrasound Microvessel Imaging (UMI) Using Deconvolution with Total Variation Regularization,” Ultrasound in Medicine and Biology, vol. 47, no. 4, pp. 1089-1098, 2021.
- Lok UW, Song P, Trzasko JD, Daigle RE, Borisch EA, Huang C, Gong P, Ling W, Chen S*, “Real time SVD-based clutter filtering using randomized singular value decomposition and spatial downsampling for micro-vessel imaging on a Verasonics system”, Ultrasonics, vol. 107, 106163, pp. 1-11, 2020.
- Gong P†, Song P†, Kolbe AB, Sheedy SP, Huang C, Ling W, Yu Y, Lok UW, Tang S, Knudsen JM, Bruining DH, Chen S*, “Quantitative Inflammation Assessment of Inflammatory Bowel Disease Using Ultrafast Ultrasound Microvessel Imaging: A Pilot Study” Journal of Ultrasound in Medicine, 39:1819-1827, 2020.
- Tang S†, Cuellar Ramos C†, Song P, Islam R, Huang C, Wen H, Knudsen BE, Lee KH, Gong P, Lok UW, Chen S, Lavrov IA*, “Changes in Spinal Cord Hemodynamics Reflect Modulation of Spinal Network with Different Parameters of epidural Stimulation,” NeuroImage 221:117183, 2020.
- Song P†, Cuellar Ramos C†, Tang S, Islam R, Wen H, Huang C, Manduca A, Trzasko JD, Knudsen BE, Lee KH, Chen S*, Lavrov IA*, “Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Electrical Stimulation: A Feasibility Study,” Frontiers in Neurology, vol. 10, no. 279, pp. 1-13, 2019.
- Gong P†, Song P†, Huang C, Fazzio RT, Ruddy KJ, Ghosh K, Meixner DD, Ling W*, Chen S, “Ultra-sensitive Ultrasound Microvessel Imaging for Characterizing Benign and Malignant Breast Tumors,” Ultrasound in Medicine and Biology, vol. 45, issue 12, pp. 3128-3136, 2019.
- Huang C, Song P, Gong P, Trzasko JD, Manduca A, Chen S*, “Debiasing-based Noise Suppression for Ultrafast Ultrasound Microvessel Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 66, no. 8, pp. 1281-1291, 2019.
- Huang C†, Lowerison MR†, Lucien F, Wang D, Gong P, Song P*, Chen S*, “Noninvasive Contrast-Free 3D Evaluation of Tumor Angiogenesis with Ultrasensitive Ultrasound Microvessel Imaging,” Scientific Reports, vol. 9, no. 1, pp. 4907, 2019.
- Song P, Manduca A, Trzasko JD, Chen S*, “Letters: Noise Equalization for Ultrafast Plane Wave Microvessel Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 64, issue 11, pp. 1776-1781, 2017.
- Song P, Trzasko JD, Manduca A, Qiang B, Kadirvel R, Kallmes DF, Chen S*, “Accelerated Singular Value-Based Ultrasound Blood Flow Clutter Filtering with Randomized Singular Value Decomposition (rSVD) and Randomized Spatial Downsampling,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 64, no. 4, pp. 706-716, 2017.
- Song P, Manduca A, Trzasko JD, Chen S*, “Ultrasound Small Vessel Imaging with Block-wise Adaptive Local Clutter Filtering,” IEEE Transactions on Medical Imaging, vol. 36, no. 1, pp. 251-262, 2017.